Center for Cancer Nanotechnology Excellence Focused on Therapy Response

Principal Investigator:

Sanjiv Sam Gambhir, M.D., Ph.D., Stanford University

Overview

This collaborative effort brings together scientists and physicians from Stanford University, the University of California, Los Angeles (UCLA), Cedars-Sinai Medical Center, Fred Hutchinson Cancer Research Center, University of Texas at Austin, Intel, and General Electric. This team will focus on using nanotechnology to advance both ex vivo, i.e., laboratory-based, diagnostics and in vivo molecular imaging, and that the combined use of these nanotechnology-enabled diagnostic tools can markedly impact future cancer patient management. In addition to general oncology applications, this CCNE will focus in particular on prostate cancer.

Specific project goals include the development of:

• Nanotube-nanowire and nanoscale magnetic devices for detecting rare proteins
• Multiplexed protein phosphorylation detection device based on Raman sensors
• Devices for profiling proteins on cell surfaces
• Targeted quantum dots for molecular imaging in living subjects

Member Institutions:

• Stanford University
• Cedars-Sinai Medical Center, Los Angeles
• FHCRC, Seattle
• UCLA
• University of Texas, Austin

Private Sector Members:

• GE Global Research Center, Niskayuna, NY
• Intel, Santa Clara, CA

Projects (Principal Investigators):

• Magneto-nano protein chip and multiplex sorter for monitoring tumor markers (Shan Wang)
• Multiplex nanotube based protein nano-arrays for cancer research (Hongjie Dai)
• Multiparameter nanoparticle detection of phosphorproteins (Garry Nolan)
• Proteomic predictors of clinical outcome of targeted therapies in prostate cancer (David Agus, Cedars-Sinai)
• Peptide-coated quantum dots for in vivo tumor targeting and multimodality imaging (Shimon Weiss, Cedars-Sinai)
• Biological modification of quantum dots for in vivo imaging (Anna Wu, UCLA)
• Mouse cancer models for integrated tissue/serum proteomics and molecular imaging (Sam Gambhir)

Cores (Prinicipal Investigators):

• Stanford Nanocharacterization Laboratory (Robert Sinclair)
• Service facility for fabricated Nanocharacterization laboratory (Yoshio Nishi)
• In vivo small animal imaging resource (Craig Levin)
• Bioinformatics and biostatistics resource (Sylvia Plevritis)

Related Links:

Molecular Imaging Program at Stanford

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